Monday, 6th July 2026
| 09:00 | 09:10 | Welcome & Opening Remarks Organising committee |
Session 1. Replication initiation and chromatin feature (1/2)
Chair: Juan Méndez (Spanish National Cancer Research Center (CNIO), Spain)
| 09:10 | 09:35 | The EMBO Keynote Lecture: Karim Labib (University of Dundee, UK) Mitotic processing of DNA replication forks |
| 09:35 | 09:55 | Scott Churcher (CBMSO, Spain) Changes in replisome composition throughout the mESC S phase |
| 09:55 | 10:15 |
Yicong Chen (Helmholtz Munich, Germany)
Investigating the co-option of transposable elements in the context of DNA replication
|
10:25–10:55 Coffee Break
Session 1. Replication initiation and chromatin feature (2/2)
Chair: Zoi Lygerou (University of Patras, Greece)
| 10:55 | 11:15 | Ran Tong (CBM, Spain) Exploring the Role of Chromatin Remodelers during mESC Primed-to-Naïve Transition |
| 11:15 | 11:30 | Helen Pynor Art show |
| 11:30 | 11:50 |
Selected talk: Anton Goloborodko (IMBA, Austria)
Conformational asymmetry of replicated human chromosomes
|
| 11:50 | 12:15 |
Anja Groth (Danish Cancer Institute, Denmark)
How cells copy their epigenome
|
12:25–14:00 Lunch Break
Session 2. Replication and Ubiquitin (1/2)
Chair: Titia Sixma (Netherlands Cancer Institute, the Netherlands)
| 14:00 | 14:25 |
Julien Stingele (LMU, Germany)
HMCES promotes theta-mediated end joining of complex DNA double-strand breaks
|
| 14:25 | 14:45 |
Utkarsha Pande (Lead Discovery Center GmbH, Germany)
High-throughput screening to identify small-molecules inhibiting PICH ATPase activity
|
| 14:45 | 15:10 |
Helle Ulrich (Institute of Molecular Biology (IMB) Mainz, Germany)
Regulation of replicative DNA damage bypass by the ubiquitin system
|
| 15:10 | 15:25 |
Pei-Ying Lin
Art show
|
15:25–17:00 Coffee Break & Poster Session
Session 2. Replication and Ubiquitin (2/2)
Chair: Matthias Altmeyer (University of Zurich, Switzerland)
| 17:00 | 17:20 | Selected talk: Beatrice Rondinelli (CNRS/Gustave Roussy Institute, France)
From enhancer regulation to genome integrity maintenance: redefining the functional landscape of the methyltransferase KMT2D
|
| 17:20 | 17:50 | Virginia Pasti (University of Zurich, Switzerland) & Kaustav Majumder (Netherlands Cancer Institute, the Netherlands)
Elucidating the regulations and functions of PAR-targeted ubiquitylation
|
| 17:50 | 18:15 |
Franziska Bleichert (Yale University, US)
New insights into the role of ATP hydrolysis during MCM loading
|
Tuesday, 7th July 2026
Session 3. Replication related immune response towards cancer (1/2)
Chair: Lorenza Penengo (University of Zurich, Switzerland)
| 09:00 | 09:25 |
John Diffley (The Francis Crick Institute, UK)
How the DNA Damage Checkpoint Maintains Replication Fork Stability
|
| 09:25 | 09:45 |
Alexander Haider (University of Patras, Greece)
Licensing system aberrations, from replication stress to inflammation
|
| 09:45 | 10:05 |
Silpa Mary Johnson (Institute of Human Genetics, CNRS, France)
Characteristics of Replication stress-induced cytosolic DNA
|
10:05–10:45 Coffee Break
Session 3. Replication related immune response towards cancer (2/2)
Chair: Philippe Pasero (IGH, CNRS & University of Montpellier, France)
| 10:45 | 11:05 |
Julius Thomas (University of Zurich, Switzerland)
Exploiting interferon/ISG15 pathway as a new vulnerability in BRCA-deficient cancer cell
|
| 11:05 | 11:20 | Solveig LillArt show |
| 11:20 | 11:40 |
Elena Pietrini (CABIMER, Spain)
Impact and therapeutic opportunities of FHIT-loss in cancer
|
| 11:40 | 12:05 |
Jessica Downs (The Institute of Cancer Research, UK)
Interplay between the ARID1A subunit of SWI/SNF and TOP2A
|
12:15–14:00 Lunch Break
Session 4. Genome Stability & DNA Repair (1/2)
Chair: Sylvie Noordermeer (Leiden University Medical Center, Oncode Institute, the Netherlands)
| 14:00 | 15:00 |
The Keynote Lecture: David Cortez (Vanderbilt University, US)
Interrogating replication and genome maintenance mechanisms via iPOND proteomics
|
| 15:00 | 15:25 |
Felipe Cortés-Ledesma (CNIO, Spain)
A role for TDP2 in resolving topological transcription-replication conflicts
|
| 15:25 | 15:45 |
Marta Oliva-Santiago (University of Copenhagen, Denmark)
How does ATR regulate DNA damage bypass?
|
| 15:45 | 16:10 |
Petr Cejka (Institute for Research in Biomedicine, Switzerland)
MRN and the BRCA1-WRN-exonuclease axis remove DNA-PK from DNA ends to promote homologous recombination
|
16:20–16:50 Coffee Break
Session 4. Genome Stability & DNA Repair (2/2)
Chair: Julien Duxin (University of Copenhagen, Denmark)
| 16:50 | 17:15 |
Stephan Hamperl (Helmholtz Munich, Germany)
Aquarius RNA helicase Protects Pluripotent Stem Cell Identity
|
| 17:15 | 17:35 |
Ho My Phuc Vo (Leiden University Medical Center, Oncode Institute, The Netherlands)
Genome-scale CRISPR-Cas9 dropout screen reveals EXO1 synthetic lethality in human RPE1 cells
|
| 17:35 | 17:55 |
Selected talk: Barbara Conradt (University College London, UK)
The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo
|
| 17:55 | 18:20 |
Dana Branzei (University of Duisburg-Essen, Germany)
Molecular basis for replisome hub- and associated DNA helicase-mediated DNA damage tolerance regulation
|
| 18:20 | 18:30 | Closing Remarks RepliFate |
RepliFate 2026
Contact
For questions or further information, please contact us by email at: munichmeeting@cbm.csic.es
Acknowledgements
This event is made possible by the support of our funding bodies and partners.
