It is not always safe to repair DNA Damage. Sometimes, cells “just bypass it”.
This review takes a fresh look at how cells replicate damaged DNA. During DNA replication, repair of lesions on DNA can be dangerous. Cells instead “tolerate” DNA damage and focus on finishing replication.
This review, by Sidak Minocha, RepliFate members Marta Oliva-Santiago and Julien Duxin, and Sampath Amitash Gadi from the Biotech Research & Innovation Centre (BRIC) at the University of Copenhagen, revisited lesion bypass in light of recent advances.
