From basic science to industrial exploitation
We will optimise cancer diagnosis and treatment
We are a doctoral network focused on understanding how DNA replication shapes cell fate and determines cancer development. Our work will identify unexpected targets within the replication machinery resulting in novel therapeutic approaches in cancer and other diseases.
Traditionally, alterations in DNA replication have been interpreted as a consequence of modifications in the transcriptional status of the cell, the structure of chromatin or the response to stress. Our proposal represents a paradigm shift in which modulating DNA replication is the means and not the consequence of chromatin changes that underlie cell fate and cancer development.
A multi-perspective strategy
Different approaches to
understand DNA replication
Our research program is articulated in four interconnected but independent work packages (WP)
that converge to characterize DNA replication as a driver of cell fate decisions.
WP1 – Understand
DNA replication mechanism dealing with stress
Using biochemical, molecular, and structural studies, we will reveal how the process of
DNA replication is modified to enable cells to answer to genotoxic and endogenous stresses.
WP2 – Drive
DNA replication determining cell fate
Through the development of new imagine techniques, genetic perturbations, and integrative functional genomics, we will test if the DNA replication by itself drives the process of cell differentiation.
WP3 – Respond
DNA replication mediating inflammatory response
By combining microfluidics, proteomics, and live imaging, we will identify the nature of cytosolic DNA in cells exposed to genotoxic agents and to dissect the role of interferon signaling in DNA replication, replication stress and chemo-resistance.
WP4 – Target
DNA replication targets for cancer therapeutics
Employing chemical biology, state-of-the-art screenings, animal models and drug development, we will exploit DNA replication alterations occurring in cancer cells to identify and develop new treatment strategies.