The candidate will primarily focus on identifying and characterizing mechanisms of DNA damage tolerance (DTT) that are activated when DNA replication forks encounter DNA damage. To this end, the candidate will combine in vitro biochemical and structural studies using Xenopus egg extracts with in vivo cellular work. The candidate will have access to all the state-of-the art facilities present at CPR including the Mass Spectrometry, Protein Imaging, Genomic Sequencing, Protein Production, and Cryo-EM platforms. Importantly, the student will incorporate the Copenhagen highly stimulating scientific environment, which has a big focus on genome maintenance mechanisms.
What does the candidate have to offer?
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
You have a MSc in biomedical sciences or equivalent
You are experienced in Molecular biology, Biochemistry or Chemistry
Proficient communication skills and ability to work in teams
The Center for Protein Research is part of the Faculty of Health and Medical Sciences at the University of Copenhagen. The center consists of 16 independent research groups divided into 5 complementary programs that combine advanced technologies and expertise in protein research, supported by state-of-the-art technological platforms for mass spectrometry, protein production and structure (with cryo-EM facility), large data management, genome sequencing and advanced microscopy. CPR’s vision is to become a world-leading research center in exploring how protein post-translational modifications (PTMs) and their functional networks drive fundamental biological processes underlying health and disease. This is fostered by housing independent and complementary research groups under one single establishment. The Duxin group belongs to the Protein Signaling Program, which includes the groups of Jiri Lukas (chromosome stability and dynamics), Niels Mailand (ubiquitin signaling in genome maintenance) and Jakob Nilsson (protein phosphatases and regulatory pathways).
Do you have any questions or do you require additional information? Please contact: Dr/Prof Julien Duxin (firstname.lastname@example.org)
Funded by the European Union under grant agreement N.101046314. Views and opinions are those of the author(s) only and do not necessarily reflect those of the European Union.