New Study Reveals PARP1’s Critical Role in Repairing DNA-Protein Crosslinks
Researchers from RepliFate have uncovered a novel DNA repair pathway orchestrated by the enzyme PARP1 that targets toxic DNA-protein crosslinks (DPCs). The study, published in Nature Communications, provides new insights into how cells handle these dangerous lesions and may explain the synergistic effects of certain cancer treatments. Key findings: PARP1 senses DPCs on single-stranded DNA gaps and those flanked by DNA nicks, like topoisomerase 1 cleavage complexes (TOP1ccs) PARP1 directly modifies the crosslinked proteins with poly(ADP-ribose) chains This PARylation triggers ubiquitination and subsequent degradation of the DPCs by the proteasome and other proteases Without PARP1-mediated [...]
Philippe Pasero (CNRS) elected to EMBO Membership
In RepliFate we are very happy and proud to congratule Philippe Pasero for his election as EMBO member. It is an honor to count with him as a member of the network. read the original article
October 16-17 MSCA ITN Replifate Meeting in Baeza
The beautiful Baeza served as the backdrop for the MSCA ITN Replifate first annual meeting, a two-day event combining network introductions, research presentations, and PhD fellow training. Dr. Emilio Lecona's warm welcome marked the start, introducing the Replifate initiative. Six PhD fellows presented their projects on day one, with Prof. Karlene Cimprich delivering an insightful keynote on 'The Causes and Consequences of Replication Stress.' The second day featured another 6 fellows presenting their research, followed by FCAECC's valuable training on Patient engagement and funding opportunities. The meeting was a fruitful blend of science and [...]
November 21-22 Replifate celebrated its kick-off meeting in Madrid
The first day was filled with exciting research as all supervisors shared their ongoing science in a well-visited symposium open to the public at the CBMSO. The second day the supervisors discussed the proposed student projects and training opportunities. It was a fantastic meeting where the supervisors also had time to interact with our advisory board and some of the associated partners. Click here to view the document
